6
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11120 |
Duocarmycin TM
|
DNA Alkylation; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Duocarmycin TM 是一种有抗肿瘤活性的抗生素,也是一种 DNA 烷化剂。 | |||
T0923 |
Busulfan
Myleran,Sulphabutin,白消安,Busulphan |
Apoptosis; DNA Alkylator/Crosslinker; DNA Alkylation | Apoptosis; DNA Damage/DNA Repair |
Busulfan (Busulphan) 是二甲磺酸盐的合成衍生物,具有抗肿瘤和细胞毒特性。是一种烷化剂,对骨髓具有选择性免疫抑制作用。 | |||
T1488 |
Procarbazine hydrochloride
NSC-77213 HCl,盐酸甲基苄肼,Procarbazine HCl |
DNA Alkylator/Crosslinker; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Procarbazine hydrochloride (NSC-77213 HCl) 是一种烷化剂,是甲基肼衍生物的盐酸盐,具有抗肿瘤和诱变活性。 | |||
T31551 |
Mipicoledine
DMCHOCPEN,DM-CHOC-PEN,DM CHOC PEN |
||
DM-CHOC-PEN is a DNA alkylation agent that may be used to treat brain cancer. | |||
T11118 |
Duocarmycin SA
|
Others | Others |
Duocarmycin SA is an extremely potent cytotoxic agent and antitumor antibiotic that induces sequence-selective alkylation of duplex DNA, with an IC50 of 10 pM. It demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells when combined with proton radiation in vitro. | |||
T10973 |
DC41SMe
|
Others | Others |
DC41SMe is a DC1 derivative that is cytotoxic to Ramos, Namalwa and HL60 / s with IC50s ranging from 18-25 pM. DC1 is a simplified analogue of CC-1065, an antibody conjugate of cytotoxic DNA alkylation molecules, used for targeted treatment of cancer. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10018 | 1-Methyladenine | Others | Others |
1-Methyladenine is a DNA alkylation product that undergoes damage reversal through oxidative demethylation for repair purposes. |